Endocrine Abstracts

Introduction: Several levothyroxine (LT4) monotherapy dose regimen have been already proposed by different medical scientists which may result in various daily LT4 doses. Comparing the consequences of such dose regimen are rather difficult since they have to be applied on either the same patient or a large study groups. Therefore, a straight forward method would be to simulate the plasma level of thyroid hormones of virtual-patients treated by various dose regimen.<p class...

Clinicians recognize patients persistently experience residual symptoms of thyrotoxicosis or hypothyroidism etc. despite having achieved circulating levels of TSH and FT4 within the conventional normal ranges. In fact, many pathological conditions affect preferred TSH and FT4. In addition, evidences indicate that the laboratory-quoted normal thyroid hormones as well as TSH reference range could not be always appropriate for everyone in clinical practice. In neonates, infants, ...

Conventionally, physicians adjust LT4 dose by clinical estimation based on their experiences and available guidelines; however, no computational algorithm exists to support their decisions. The objective of this study is to build an artificial decision support system utilizing fuzzy logic to propose a proper LT4 dosage regimen. We used THYROSIM software as the model of human thyroid hormone regulation to simulate a virtual thyroidectomized patient, setting the secretion rates ...